#3. Maintaining Screen Direction
As long as you continue to establish any new screen spacing or direction, the sequence should maintain a certain level of continuity that will allow the audience to follow along quite easily.
Always remember, sometimes the information you withhold from the audiene can create some nice comedic effects when you reveal that information to them.
Take a look at these rough boards from The Iron Giant, you can see the artistic differences between various storyboard artists, but the compositions are clear and dynamic everytime.